In today's society, the rapid development of science and technology system, automatic voice call being more and more applied to daily life, design, use MAX232 89C51 for controller, and realize the data communication between computers. Given 89C51 89C51 and MT8880 connected with MAX232 connected with the software and hardware design. The design on the circuit design and MT8880 transceiver ISD2560 circuit, and recording of the chip AT89S52 SCM control. Automatic voice call system in the life of the application is not so easy to provide convenience for the people, in the spare time and virtually created additional value. In today's society, the rapid development of science and technology system, automatic voice call being more and more applied to daily life, design, use MAX232 89C51 for controller, and realize the data communication between computers. Given 89C51 89C51 and MT8880 connected with MAX232 connected with the software and hardware design. The design on the circuit design and MT8880 transceiver ISD2560 circuit, and recording of the chip AT89S52 SCM control. Automatic voice call system in the life of the application is not so easy to provide convenience for the people, in the spare time and virtually created additional value.